Осложнения при проведении процедуры седации закисью азота в детской стоматологической практике

Стоматологическая седация — это метод, который стоматологи могут использовать, чтобы уменьшить беспокойство и страх пациентов и обеспечить эффективное стоматологическое лечение [1]. Однако не все виды седации в стоматологии можно назвать абсолютно безопасными, неправильный выбор препарата может привести к тяжелым последствиям. Целью этого систематического обзора было провести анализ актуальных данных по осложнениям при проведении процедуры седации, в частности закисью азота в детской стоматологической практике. Исследование проводилось с использованием PubMed, Google Scholar и, Wiley Online Library, Cyberleninka, ограничиваясь статьями на английском и русском языке. Основным типом седации, используемым для стоматологических пациентов детского возраста, является ингаляционный метод, известный как “относительная анальгезия”, при котором используется закись азота (смесь азота и кислорода). Ингаляция закиси азота и кислорода признается как безопасный и эффективный метод снижения тревожности, обезболивания и улучшения коммуникации между пациентом и доктором. Редкие побочные эффекты все же наблюдаются, их изучению будет посвящен этот обзор литературы, чтобы в дальнейшем избежать осложнений и получить наилучший результат лечения.

Dental sedation is an advanced method that dentists can perform to reduce patients’ anxiety and fear and provide effective dental treatment. However, not all types of sedation in dentistry can be called absolutely safe, the wrong choice of the drug can lead to serious consequences. The purpose of this systematic review was to analyze current data on complications during sedation procedures, in particular nitrous oxide in pediatric dental practice. The research was conducted using PubMed, Google Scholar and Wiley Online Library, Cyberleninka and limited to articles in English and Russian. The main type of sedation used for pediatric dental patients is an inhalational technique known as ‘relative analgesia’, which uses nitrous oxide in oxygen. Inhalation with nitrous oxide/oxygen is recognized as a safe and effective method of reducing anxiety, pain relief and improving communication between the patient and the doctor. Rare side effects are still observed, the study of which will be devoted to this literature review in order to avoid complications in the future and get the best treatment result.

седация, закись азота, детская стоматология, осложнения.

sedation, nitrous oxide, pediatric dentistry, complications.

/ References:
1. Шугайлов И.А, Агафонова А.В, Сергеева Ю.И., Миргазизов М. Метод ингаляционной премедикации ксенон-кислородной смесью в детской стоматологической практике // ЭкоВектор. - 2019. - № 23, № 3-4 . - С. 123-128 [SHugajlov I.A, Agafonova A.V, Sergeeva YU.I., Mirgazizov M. Metod ingalyacionnoj premedikacii ksenon-kislorodnoj smes’yu v detskoj stomatologicheskoj praktike // EkoVektor. - 2019. - № 23, № 3-4 . - S. 123-128.].
2. Zier, Judith L., Liu, Meixia. Safety of High-Concentration Nitrous Oxide by Nasal Mask for Pediatric Procedural Sedation // Pediatric Emergency Care. - 2011. - № 27 (12). - P. 1107-1112.
3. Vineet Khinda, Dinesh Rao, Surender PS Sodhi, Gurlal S Brar, and Nikhil Marwah. Physiological Effects, Psychomotor Analysis, Cognition, and Recovery Pattern in Children Undergoing Primary Molar Extractions under Nitrous Oxide Sedation Using Two Different Induction Techniques: A Split-mouth Randomized Controlled Clinical Trial // Int J Clin Pediatr Dent. - 2021. - № 14. - P. 131-137.
4. Unkel John H; Alexander C Ian; Berry Elizabeth; Reinhartz Judy; Reinhartz Dennis. Effectiveness and Safety of Elevated Dosages of Nitrous Oxide on Behavior Management in Pediatric Dentistry // Clinical Pediatric Dentistry. - 2022. - № 46 (1). - P. 58-61.
5. Thomas Bean, Glenda Aruede. Conscious Sedation in Dentistry // NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. - 2023.
6. Stephen Wilson. Wright’s Behavior Management in Dentistry for Children. - 3-e изд. - 2021. Sedation for the Pediatric Patient. - Chapter 11.
7. Shivani Mathur, Tushar Pruthi, Vinod Sachdev, Rahul Chopra, Sakshi Jain. Epistaxis during Inhalation Sedation Using Nitrous Oxide: Report of a Rare Case // Journal of South Asian Association of Pediatric Dentistry. - 2020. - Volume 3, Issue 2. - P. 92-94.
8. Seong In Chi. Complications caused by nitrous oxide in dental sedation // Dental Anesthesia and Pain Medicine. - 2018. - № 18 (2). - P. 71-78.
9. Santhosh Priya AKR, Jayanthi Mungara, Poornima Vijayakumar, Gayathri Murali and Akila Veerapandian. Assessment of Effectiveness Acceptability Complications and Parental Satisfaction of Pediatric Dental Patients Treated under Nitrous Oxide-oxygen Inhalational Sedation Using Porter Silhouette Mask // Clinical Pediatric Dentistry. - 2022. - № 15 (5). - P. 493-498.
10. Priyanshi Ritwik Nitrous. Oxide in Pediatric Dentistry. - 2020. Sedation Using Nitrous Oxide in Children with Special Health Care Needs. - P. 241-256.
11. Palak Janiani,Deepa Gurunathan and Sivakumar Nuvvula. Influence of Temperament on the Acceptance of Two Conscious Sedation Techniques in Toddlers Undergoing Dental Treatment: A Randomised Cross Over Trial // Hindawi URL: https://www.hindawi.com/journals/prm/2023/6655628/ (дата обращения: 01 Jun 2023).
12. Pablo Osvaldo Sepúlveda, Paulo Sérgio Sucasas da Costa. Pediatric Sedation Outside of the Operating Room. - 2021. Pediatric Sedation in South America. - P. 587-599.
13. Nishkarsh Gupta, Anju Gupta, and Vishnu Narayanan M R. Current status of nitrous oxide use in pediatric patients // Clinical Pediatrics. - 2022. - № 11 (2). - P. 93-104.
14. Neethu Ann Preethy and Sujatha Somasundaram. Safety and physiologic effects of intranasal midazolam and nitrous oxide inhalation based sedation in children visiting Saveetha Dental College and Hospitals // Bioinformation. - 2022. - № 18 (1). - P. 26-35.
15. Navaneetha Krishnan Srinivasan, Pradeep Karunagaran, Veerale Panchal, corresponding author and EMG Subramanian Comparison of the Sedative. Effect of Inhaled Nitrous Oxide and Intranasal Midazolam in Behavior Management and Pain Perception of Pediatric Patients: A Split-mouth Randomized Controlled Clinical Trial // Clinical Pediatric Dentistry. - 2021. - № 14 (Suppl 2). - P. 111-116.
16. Minjae Lee, Seong In Chi, Hyuk Kim and Kwang-Suk. Analysis of the annual changes in dental institutions that claimed dental sedatives in Korea and the types of sedatives using health care big data // Dental Anesthesia and Pain Medicine. - 2023. - № 23 (2). - P. 101-110.
17. Lucia Memè, Gianni Gallusi, Enrico Strappa, Fabrizio Bambini and Francesco Sampalmieri Conscious Inhalation Sedation with Nitrous Oxide and Oxygen in Children: A Retrospective Study // Applied Sciences . - 2022. - № 12 (22).
18. Kunal Gupta, Priyanshi Ritwik. Rationale and pre-requisites for use of nitrous oxide in pediatric dentistry // Clinical Dentistry Reviewed volume. - 2021. - № 5.
19. Kunal Gupta, Dimitrios Emmanouil, Amit Sethi. Nitrous Oxide in Pediatric Dentistry: A Clinical Handbook. - Cham, Switzerland: 2019. - 323 p.
20. Kunal Gupta, Dimitrios Emmanouil, Amit Sethi. Nitrous Oxide in Pediatric Dentistry. - 2020. Mechanism of Action of Nitrous Oxide - 77-108 p.
21. Kunal Gupta, Dimitrios Emmanouil and Amit Sethi Use of nitrous oxide-oxygen inhalation sedation in the COVID-19 era // Int J Pediatr Dent. - 2021. - № 31 (3). - P. 433-435.
22. Kunal Gupta & Priyanshi Ritwik. The “First Nitrous Oxide Visit” in a pediatric dental practice // Clinical Dentistry Reviewed. - 2021. - № 5.
23. Kunal Gupta & Amit Sethi. Nitrous Oxide in Pediatric Dentistry. - 2020. Risks of Nitrous Oxide. - 207-240 p.
24. Kelly Fernanda Molena, Ricardo Barbosa Lima, Taíssa Cássia de Souza Fortunato, Alexandra Mussolino de Queiroz Fabrício Kitazono de Carvalho, Maya Fernanda Manfrin Arnez, Francisco Wanderley Garcia Paula-Silva. Case Report: Applicability of sedation with nitrous oxide in the management of molar incisor hypomineralization in pediatric patients // Frontiers in Dental Medicine Sec. Pediatric Dentistry Volume 3. - 2022.
25. Katrin Bekes & Richard Steffen. Behavior management and pain control in treatment of children with molar incisor hypomineralization // Clinical Dentistry Reviewed volume 5 Article number: 20. - 2021.
26. Karishma, a; Kohli, Sonamb; Rajeesh, Mohammed P.K.c; Balan, Ushad; Choudhury, Basanta K.e; DSouza, Henstonf. Efficacy of nitrous oxide-oxygen inhalation versus oral midazolam-promethazine as sedative agents in pediatric patients // Egyptian Pharmaceutical Journal. - 2022. - № 21 (4). - P. 526-530.
27. Johny Kharouba; Mostafa Somri; Christopher Hadjittofi; Jomana Hasan; Sigalit Blumer. Effectiveness and Safety of Nitrous Oxide as a Sedative Agent at 60% and 70% Compared to 50% Concentration in Pediatric Dentistry Setting // Clinical Pediatric Dentistry. - 2020. - № 44 (1). - P. 60-65.
28. Ishfaq Khan. Postoperative Epistaxis Following Dental Treatment With Nitrous Oxide/Oxygen Sedation // Anesth Prog. - 2023. - № 70 (2). - P. 75-79.
29. Irfan, Mohammed; Lund, Rafael; Kumar, Santosh. Professional Negligence During Nitrous Oxide Sedation and Child Fatality in Dental Office and Suggested Precautions A Short Communication on Childcare and Nitrous Oxide Sedation // Advances in Human Biology. - 2020. - № 10 (1). - P. 3-5.
30. Gurman Pal Mallhi. Nitrous Oxide Sedation: A Review // MAR Dental Sciences. - 2021. - Volume 3 Issue 2. - P. 1-8.
31. Ferrazzano GF, Quaraniello M, Sangianantoni G, Ingenito A, Cantile T. Clinical effectiveness of inhalation conscious sedation with nitrous oxide and oxygen for dental treatment in uncooperative paediatric patients during COVID-19 outbreak // Paediatric Dentistry. - 2020. - № 21 (4). - P. 277-282.
32. Feng Gao, Yujia Wu. Procedural sedation in pediatric dentistry: a narrative review // Front. Med. - 2023. - volume 10.
33. Elin Brathen, An Boudewyns, Stijn Verhulst, Ann Roete, Joris Verlooy, Nathalie van Meerbeeck, Olivier Vanderveken, Nicolien van der Poel. Effectiveness of nitrous oxide sedation for otolaryngologic examination in the outpatient clinic in uncooperative children // Pediatric Otorhinolaryngology. - Volume 162. - 2022.
34. Dimitris Emmanouil. Pediatric Sedation Outside of the Operating Room. - 2021. The Pharmacology, Physiology and Clinical Application in Dentistry of Nitrous Oxide. - 199-209 p.
35. Dimitrios Velonis, Dimitrios Emmanouil, Keira P. Mason Pediatric Dentistry. - 2022. Pharmacologic Behavior Management (Sedation - General Anesthesia). - 131-153 p.
36. Claudia Salerno, Silvia Cirio, Giulia Zambon, Valeria D’Avola, Roberta Gaia Parcianello, Cinzia Maspero, Guglielmo Campus and Maria Grazia Cagetti. Conscious Sedation for Dental Treatments in Subjects with Intellectual Disability: A Systematic Review and Meta-Analysis
// Environmental Research and Public Health. - 2023. - № 20 (3).
37. Booij L. H. D. Hj. The history of nitrous oxide. Should it still be used in pediatric medicine? (part 2) // Medical news of north caucasus. - 2018. - Volume 13, Issue 3. - P. 549-552.
38. Booij L. H. D. Hj. Nitrous oxide. Should it still be used in pediatric medicine? (part 1) // Medical news of north caucasus. - 2017. - Volume 12, Issue 3. - P. 347-351.
39. Annelyse Garret-Bernardin, Paola Festa, Giorgio Matarazzo, Arina Vinereanu, Francesco Aristei, Tina Gentile, Simone Piga, Elena Bendinelli, Maria Grazia Cagetti and Angela Galeotti Behavioral Modifications in Children after Repeated Sedation with Nitrous Oxide for Dental Treatment: A Retrospective Study // Environmental Research and Public Health. - 2023. - № 20 (5).
40. Angela Galeotti,Annelyse Garret Bernardin,Vincenzo D’Antò,Gianmaria Fabrizio Ferrazzano,Tina Gentile,Valeria Viarani,Giorgio Cassabgi and Tiziana Cantile. Inhalation Conscious Sedation with Nitrous Oxide and Oxygen as Alternative to General Anesthesia in Precooperative, Fearful, and Disabled Pediatric Dental Patients: A Large Survey on 688 Working Sessions // Hindawi URL: https://www.hindawi.com/journals/bmri/2016/7289310/ (дата обращения: 06 Aug 2016).
41. Alexandre Perez, Steven Gernandt and Paolo Scolozzi. The Use of Equimolar Mixtures of Nitrous Oxide and Oxygen in Oral Surgery - A Retrospective Study of Patients in a Swiss University Hospital Setting // J. Clin. Med. - 2023. - № 12 (12).